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A new study presents evidence that hormonal changes, from monthly cycles to menopause, significantly alter how the brain processes sound. By highlighting that men and women follow entirely different auditory decline trajectories, this research calls for a “precision audiology” approach that accounts for sex-dependent variability to improve care for all.​ 

Can we “hotwire” the brain to fix neurological disorders? Researchers have unveiled LinCx, a technology that creates biological electrical “bypasses” between neurons. By engineering fish-derived proteins to act as precision wires, the team successfully reshaped brain activity and behavior in mice without the need for drugs or external electrodes. This “cellular editing” marks a major

Can autism’s core traits be separated from cognitive ability? Researchers have identified PTCHD1-AS, a long non-coding RNA gene that regulates social interaction and repetitive behaviors without affecting learning or memory. By tracing this gene’s influence to synaptic plasticity in the striatum, the study provides a “molecular pattern” for future precision treatments aimed specifically at the

Researchers have identified three distinct genetic pathways that explain how Cannabis Use Disorder (CUD) leads to psychosis. By analyzing over 500 genetic markers and the role of the glutamate system, which is heavily impacted by THC, the team has laid the groundwork for precision models to identify high-risk users and develop targeted treatments for cannabis-related

A “first of its kind” personalized DNA vaccine is doubling survival rates for patients with aggressive glioblastoma. By targeting 40 unique tumor proteins, twice as many as previous therapies, the GNOS-PV01 vaccine transforms “cold” tumors into “hot” targets for the immune system. With one patient remaining cancer-free five years late.​ 

A new study found that GPNMB, released by the brain’s immune cells, accelerates the spread of toxic alpha-synuclein. By using monoclonal antibodies to block GPNMB, the team successfully interrupted the cycle of neurodegeneration in preclinical models. This discovery provides a new therapeutic target that could finally slow the progression of Parkinson’s at its earliest stages.​ 

Researchers discovered that transposable elements (TEs) provided more than 20,000 regulatory binding sites that drive neural development. By acting as genomic couriers for transcription factors like Sox2 and Brn2, these “jumping genes” expanded the complexity of the mammalian brain, offering a new two-phase model of how our neural networks evolved.​ 

GLP-1 medications effectively “turn down the volume” on intrusive food thoughts. In a study of 417 adults, those combining medication with behavioral therapy saw a significantly greater reduction in “food noise” than those using therapy alone, offering a potential neurobiological explanation for the success of these new obesity treatments.​ 

Researchers discovered that dysregulated circadian rhythms cause microglia, the brain’s immune cells, to become “stress-primed” and malfunction. This state prevents them from clearing amyloid plaques, accelerating dementia risk. Now, using DARI seedling grants, Souza is testing a stem-cell-derived “EV therapy” designed to keep these cells healthy and prevent neuroinflammation.​ 

Researchers have developed a brain-controlled hearing system that uses real-time neural signals to solve the “cocktail party problem.” By matching a listener’s brain waves to specific voices in a crowd, the device can automatically amplify a chosen conversation while silencing others, paving the way for a new generation of “neural extension” hearing aids that align